Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD)

被引：76

作者：

Nashine, Sonali ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Ophthalmol, Irvine, CA 92697 USA

来源：

CELLS | 2021年 / 10卷 / 09期

关键词：

age-related macular degeneration (AMD); retina; AMD therapeutics; CILIARY NEUROTROPHIC FACTOR; RETINAL GANGLION-CELLS; SMALL GTPASE RAP1; OXIDATIVE STRESS; AMYLOID-BETA; CHOROIDAL NEOVASCULARIZATION; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS; GENE-EXPRESSION; CELECOXIB;

D O I：

10.3390/cells10092483

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging contributes to the risk of development of ocular diseases including, but not limited to, Age-related Macular Degeneration (AMD) that is a leading cause of blindness in the United States as well as worldwide. Retinal aging, that contributes to AMD pathogenesis, is characterized by accumulation of drusen deposits, alteration in the composition of Bruch's membrane and extracellular matrix, vascular inflammation and dysregulation, mitochondrial dysfunction, and accumulation of reactive oxygen species (ROS), and subsequent retinal pigment epithelium (RPE) cell senescence. Since there are limited options available for the prophylaxis and treatment of AMD, new therapeutic interventions are constantly being looked into to identify new therapeutic targets for AMD. This review article discusses the potential candidates for AMD therapy and their known mechanisms of cytoprotection in AMD. These target therapeutic candidates include APE/REF-1, MRZ-99030, Ciliary NeuroTrophic Factor (CNTF), RAP1 GTPase, Celecoxib, and SS-31/Elamipretide.

引用

页数：16

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