Controversies in nephrology: renal albumin handling, facts, and artifacts!

被引：50

作者：

Christensen, El

Birn, H.

Rippe, B.

Maunsbach, A. B.

机构：

[1] Univ Aarhus, Dept Cell Biol, Inst Anat, DK-8000 Aarhus C, Denmark

[2] Univ Lund Hosp, Dept Nephrol, S-22185 Lund, Sweden

来源：

KIDNEY INTERNATIONAL | 2007年 / 72卷 / 10期

关键词：

glomerular sieving coefficient; albumin fractional clearance; endocytosis; megalin; cubilin; transcytosis;

D O I：

10.1038/sj.ki.5002526

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this article, we discuss and contradict a recent publication by Russo et al., which suggests that the filtration of large amounts of albumin followed by transtubular transport of intact albumin is a physiological phenomenon.

引用

页码：1192 / 1194

页数：3

共 12 条

[1] Cubilin is an albumin binding protein important for renal tubular albumin reabsorption [J].

Birn, H ;

Fyfe, JC ;

Jacobsen, C ;

Mounier, F ;

Verroust, PJ ;

Orskov, H ;

Willnow, TE ;

Moestrup, SK ;

Christensen, EI .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (10) :1353-1361

[2] Megalin/gp330 mediates uptake of albumin in renal proximal tubule [J].

Cui, SY ;

Verroust, PJ ;

Moestrup, SK ;

Christensen, EI .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1996, 271 (04) :F900-F907

[3] Renal albumin handling: A look at the dark side of the filter [J].

Gekle, M. .

KIDNEY INTERNATIONAL, 2007, 71 (06) :479-481

[4] Why do we not all have proteinuria?: An update of our current understanding of the glomerular barrier [J].

Haraldsson, B ;

Sörensson, J .

NEWS IN PHYSIOLOGICAL SCIENCES, 2004, 19 :7-10

[5] Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys [J].

Lund, U ;

Rippe, A ;

Venturoli, D ;

Tenstad, O ;

Grubb, A ;

Rippe, B .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (06) :F1226-F1234

[6] ABSORPTION OF I125-LABELED HOMOLOGOUS ALBUMIN BY RAT KIDNEY PROXIMAL TUBULE CELLS - A STUDY OF MICROPERFUSED SINGLE PROXIMAL TUBULES BY ELECTRON MICROSCOPIC AUTORADIOGRAPHY AND HISTOCHEMISTRY [J].

MAUNSBACH, AB .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1966, 15 (3-4) :197-+

[7] Glomerular protein sieving and implications for renal failure in Fanconi syndrome [J].

Norden, AGW ;

Lapsley, M ;

Lee, PJ ;

Pusey, CD ;

Scheinman, SJ ;

Tam, FWK ;

Thakker, RV ;

Unwin, RJ ;

Wrong, O .

KIDNEY INTERNATIONAL, 2001, 60 (05) :1885-1892

[8] TIME COURSE AND VECTORIAL NATURE OF ALBUMIN METABOLISM IN ISOLATED PERFUSED RABBIT PCT [J].

PARK, CH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (03) :F520-F528

[9] ALBUMIN ABSORPTION AND CATABOLISM BY ISOLATED PERFUSED PROXIMAL CONVOLUTED TUBULES OF THE RABBIT [J].

PARK, CH ;

MAACK, T .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (03) :767-777

[10] The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states [J].

Russo, L. M. ;

Sandoval, R. M. ;

McKee, M. ;

Osicka, T. M. ;

Collins, A. B. ;

Brown, D. ;

Molitoris, B. A. ;

Comper, W. D. .

KIDNEY INTERNATIONAL, 2007, 71 (06) :504-513

← 1 2 →