Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease

被引：16

作者：

Antipova, Veronica ^{[1
,2
]}

Holzmann, Carsten ^{[3
,4
]}

Hawlitschka, Alexander ^{[1
]}

Witt, Martin ^{[1
,4
]}

Wree, Andreas ^{[1
,4
]}

机构：

[1] Rostock Univ, Inst Anat, Med Ctr, D-18057 Rostock, Germany

[2] Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, A-8010 Graz, Austria

[3] Rostock Univ, Inst Med Genet, Med Ctr, D-18057 Rostock, Germany

[4] Ctr Transdisciplinary Neurosci Rostock, D-18147 Rostock, Germany

来源：

TOXINS | 2021年 / 13卷 / 07期

关键词：

hemiparkinsonian rat; 6-OHDA; botulinum neurotoxin-A; depression; striatum; behavior; forced swim test; tail suspension test; open field test; elevated plus maze test; correlation analysis; TOXIN TYPE-A; ELEVATED PLUS-MAZE; FORCED SWIMMING TEST; DEPRESSIVE-LIKE BEHAVIORS; MEDIAL FOREBRAIN-BUNDLE; TAIL SUSPENSION TEST; STRIATAL CHOLINERGIC INTERNEURONS; DEEP BRAIN-STIMULATION; ANXIETY-LIKE BEHAVIOR; OPEN-FIELD BEHAVIOR;

D O I：

10.3390/toxins13070505

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Parkinson's patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepressant-like properties in addition to the known improvement of motor performance. To quantify depression- and anxiety-like behavior, the forced swim test, tail suspension test, open field test, and elevated plus maze test were applied to hemi-PD rats injected with BoNT-A or vehicle. Furthermore, we correlated the results in the forced swim test, open field test, and elevated plus maze test with the rotational behavior induced by apomorphine and amphetamine. Hemi-PD rats did not show significant anxiety-like behavior as compared with Sham 6-OHDA- + Sham BoNT-A-injected as well as with non-injected rats. However, hemi-PD rats demonstrated increased depression-like behaviors compared with Sham- or non-injected rats; this was seen by increased struggling frequency and increased immobility frequency. Hemi-PD rats intrastriatally injected with BoNT-A exhibited reduced depression-like behavior compared with the respective vehicle-receiving hemi-PD animals. The significant effects of intrastriatally applied BoNT-A seen in the forced swim test are reminiscent of those found after various antidepressant drug therapies. Our data correspond with the efficacy of BoNT-A treatment of glabellar frown lines in treating patients with major depression and suggest that also intrastriatal injected BoNT-A may have some antidepressant-like effect on hemi-PD.

引用

页数：37

共 397 条

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