Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics

被引：42

作者：

Hummelen, Ruben ^{[1
,2
]}

Vos, Arjan P. ^{[3
,4
]}

van't Land, Belinda ^{[3
,4
]}

van Norren, Klaske ^{[4
,5
]}

Reid, Gregor ^{[1
,6
,7
]}

机构：

[1] Canadian Res & Dev Ctr Probiot, Lawson Hlth Res Inst, London, ON N6A 4V2, Canada

[2] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands

[3] Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3508 TC Utrecht, Netherlands

[4] Danone Res Ctr Specialised Nutr, Wageningen, Netherlands

[5] Wageningen Univ, Nutr & Pharmacol Croup, Div Human Nutr, Wageningen, Netherlands

[6] Univ Western Ontario, Dept Microbiol, London, ON, Canada

[7] Univ Western Ontario, Dept Immunol & Surg, London, ON, Canada

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

HIV; AIDS; gastrointestinal tract; bacterial translocation; probiotics; prebiotics; HUMAN-IMMUNODEFICIENCY-VIRUS; COLI NISSLE 1917; CHAIN GALACTO-OLIGOSACCHARIDES; INFLAMMATORY-BOWEL-DISEASE; RANDOMIZED CLINICAL-TRIAL; MUCOSAL IMMUNE-RESPONSES; CRITICALLY-ILL PATIENTS; TUMOR-NECROSIS-FACTOR; GUT BARRIER FUNCTION; T-CELL DEPLETION;

D O I：

10.3109/08830185.2010.505310

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Intestinal immune system is severely affected by HIV and circulating microbial products from the intestinal tract that provide an ongoing source of systemic inflammation and concomitant viral replication. In addition, HIV-Infected individuals can have a deregulated immune response that may hamper the anti-viral capacity of the host. Various probiotic organisms and prebiotic agents have been shown to enhance intestinal epithelial harrier functions, reduce inflammation, and support effective Th-1 responses As these characteristics may benefit HIV patients, this review aims to provide a. theoretical framework for the development of probiotic and prebiotic interventions specifically fir this population

引用

页码：485 / 513

页数：29

共 181 条

[1] Lactobacillus casei infection in an AIDS patient [J].