Parasite glycoconjugates.: Part 11.: Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating α-D-mannopyranosylphosphate transferase in the Leishmania

被引：15
作者：
Ross, AJ
Ivanova, IA
Ferguson, MAJ
Nikolaev, AV [1 ]
机构：
[1] Univ Dundee, Dept Chem, Dundee DD1 4HN, Scotland
[2] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 01期
关键词：
D O I：
10.1039/b004653l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods for the glycosylation reactions, S(N)2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.
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页码：72 / 81
页数：10
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