Targeting lipid mediators in cancer biology

被引：46
作者：
Sulciner, Megan L. [1 ,2 ]
Gartung, Allison [1 ,2 ]
Gilligan, Molly M. [1 ,2 ]
Serhan, Charles N. [3 ]
Panigrahy, Dipak [1 ,2 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Vasc Biol Res Ctr, Boston, MA 02115 USA
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury Perioperat &, Dept Anesthesiol, Boston, MA USA
来源：
CANCER AND METASTASIS REVIEWS | 2018年 / 37卷 / 2-3期
关键词：
Bioactive lipids; Cancer biology; Specialized pro-resolving mediators; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SPHINGOSINE KINASE 1; POLYUNSATURATED FATTY-ACIDS; ACTIVATED RECEPTOR-GAMMA; BREAST-CANCER; PROSTATE-CANCER; TUMOR-GROWTH; LYSOPHOSPHATIDIC ACID; COLON-CANCER; RESOLVIN D1;
D O I：
10.1007/s10555-018-9754-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bioactive lipids are essential components of human cells and tissues. As discussed in this review, the cancer lipidome is diverse and malleable, with the ability to promote or inhibit cancer pathogenesis. Targeting lipids within the tumor and surrounding microenvironment may be a novel therapeutic approach for treating cancer patients. Additionally, the emergence of a novel super-family of lipid mediators termed specialized pro-resolving mediators (SPMs) has revealed a new role for bioactive lipid mediators in the resolution of inflammation in cancer biology. The role of SPMs in cancer holds great promise in our understanding of cancer pathogenesis and can ultimately be used in future cancer diagnostics and therapy.
引用
收藏
页码：557 / 572
页数：16
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