Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

被引：11
作者：
Chistiakov, Dimitry A. [1 ,2 ]
Bobryshev, Yuri V. [3 ,4 ,5 ]
Orekhov, Alexander N. [3 ,6 ]
机构：
[1] Res Ctr Childrens Hlth, Moscow 119991, Russia
[2] Mt Sinai Med Ctr, Mt Sinai Comprehens Canc Ctr, Mt Sinai Community Clin Oncol Program, Miami Beach, FL 33140 USA
[3] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow 125315, Russia
[4] Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
[5] Univ Western Sydney, Sch Med, Campbelltown, NSW 2560, Australia
[6] Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow 143025, Russia
来源：
MOLECULAR IMMUNOLOGY | 2015年 / 65卷 / 01期
关键词：
Atherosclerosis; Arteries; Inflammation; Immune reactions; Interleukin; 12; ACUTE CORONARY SYNDROME; APOE-DEFICIENT MICE; TH1; DIFFERENTIATION; RECEPTOR SUBUNITS; T(H)17 CELLS; IFN-GAMMA; IL-27; INTERLEUKIN-12; INDUCTION; PROLIFERATION;
D O I：
10.1016/j.molimm.2015.01.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：133 / 138
页数：6
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