Biomarkers of intestinal fibrosis - one step towards clinical trials for stricturing inflammatory bowel disease

被引：52

作者：

Giuffrida, Paolo ^{[1
]}

Pinzani, Massimo ^{[2
]}

Corazza, Gino R. ^{[1
]}

Di Sabatino, Antonio ^{[1
,2
]}

机构：

[1] Univ Pavia, San Matteo Hosp Fdn, Dept Internal Med 1, Pavia, Italy

[2] UCL, Inst Liver & Digest Hlth, London, England

来源：

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2016年 / 4卷 / 04期

关键词：

Anti-microbial antibody; Crohn's disease; extracellular matrix; growth factor; microRNA; FIBROBLAST ACTIVATION PROTEIN; COMPLICATED CROHNS-DISEASE; ANTI-GLYCAN ANTIBODIES; 4TH SCIENTIFIC WORKSHOP; LIVER FIBROSIS; GROWTH-FACTOR; SERUM-LEVELS; REMODELING INTERFACE; SEROLOGICAL MARKERS; PLASMA FIBRONECTIN;

D O I：

10.1177/2050640616640160

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intestinal fibrosis, caused by an excessive deposition of extracellular matrix components, and subsequent stricture development are a common complication of inflammatory bowel disease. However, currently there are no biomarkers which reliably predict the risk of developing intestinal strictures or identify early stages of fibrosis prior to clinical symptoms. Candidate biomarkers of intestinal fibrosis, including gene variants (i.e. nucleotide-binding oligomerization domain-2 gene), serum microRNAs (miR-19, miR-29), serum extracellular matrix proteins (i.e. collagen, fibronectin) or enzymes (i.e. tissue inhibitor of matrix metalloproteinase-1), serum growth factors (i.e. basic fibroblast growth factor, YKL-40), serum anti-microbial antibodies (i.e. anti-Saccharomyces cerevisiae) and circulating cells (i.e. fibrocytes) have shown conflicting results on relatively heterogeneous patients' cohorts, and none of them was proven to be strictly specific for fibrostenosis, but rather predictive of a disease disabling course. In this review we critically reassess the diagnostic and prognostic value of serum biomarkers of intestinal fibrosis in inflammatory bowel disease.

引用

页码：523 / 530

页数：8

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