Design and synthesis of novel chrysene-linked pyrrolo[2,1-c] [1,4]-benzodiazepine hybrids as potential DNA-binding agents

被引：36

作者：

Kamal, A ^{[1
]}

Ramesh, G ^{[1
]}

Ramulu, P ^{[1
]}

Srinivas, O ^{[1
]}

Rehana, T ^{[1
]}

Sheelu, G ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(03)00743-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3451 / 3454

页数：4

共 50 条

[21] DNA-binding properties of pyrrolo[2,1-c][1,4]-benzodiazepine N10-C11 amidines
Foloppe, MP
Rault, S
Thurston, DE
Jenkins, TC
Robba, M
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (05) : 407 - 410
[22] Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4] benzothiadiazine linked pyrrolo[2,1-c] [1,4] benzodiazepine conjugates
Kamal, Ahmed
Khan, M. Naseer A.
Srikanth, Y. V. V.
Reddy, K. Srinivasa
Juvekar, Aarti
Sen, Subrata
Kurian, Nisha
Zingde, Surekha
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (16) : 7804 - 7810
[23] Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents
Kamal, Ahmed
Reddy, M. Kashi
Ramaiah, M. Janaki
Reddy, Rajender J. Surendranadha
Srikanth, Y. V. V.
Dastagiri, D.
Bharathi, E. Vijaya
Pushpavalli, S. N. C. V. L.
Sarma, Pranjal
Pal-Bhadra, Manika
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (08) : 2565 - 2581
[24] Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
Kamal, Ahmed
Reddy, K. Srinivasa
Khan, M. Naseer A.
Shetti, Rajesh V. C. R. N. C.
Ramaiah, M. Janaki
Pushpavalli, S. N. C. V. L.
Srinivas, Chatla
Pal-Bhadra, Manika
Chourasia, Mukesh
Sastry, G. Narahari
Juvekar, Aarti
Zingde, Surekha
Barkume, Madan
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (13) : 4747 - 4761
[25] Synthesis, DNA binding, and cytotoxicity studies of pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates
Kamal, Ahmed
Ramu, R.
Tekumalla, Venkatesh
Khanna, G. B. Ramesh
Barkume, Madan S.
Juvekar, Aarti S.
Zingde, Surekha M.
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (22) : 6868 - 6875
[26] EVALUATION OF THE ELECTROPHILICITY OF DNA-BINDING PYRROLO[2,1-C][1,4]BENZODIAZEPINES BY HPLC
MORRIS, SJ
THURSTON, DE
NEVELL, TG
JOURNAL OF ANTIBIOTICS, 1990, 43 (10) : 1286 - 1292
[27] Design, synthesis, and biological evaluation of pyrrolo[2,1-c[1,4]benzodiazepine and indole conjugates as anticancer agents
Wang, JJ
Shen, YK
Hu, WP
Hsieh, MC
Lin, FL
Hsu, MK
Hsu, MH
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (04) : 1442 - 1449
[28] Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates.: Synthesis, DNA binding and cytotoxicity
Kamal, A
Ramu, R
Khanna, GBR
Saxena, AK
Shanmugavel, M
Pandita, RM
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (19) : 4907 - 4909
[29] DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents
Rahman, Khondaker M.
Vassoler, Higia
James, Colin H.
Thurston, David E.
ACS MEDICINAL CHEMISTRY LETTERS, 2010, 1 (08): : 427 - 432
[30] Design and synthesis of novel pyrrolo[2,1-c][1,4]benzodiazepine-imidazole containing polyamide conjugates
Kumar, R
Reddy, BSN
Lown, JW
HETEROCYCLIC COMMUNICATIONS, 2002, 8 (01) : 19 - 26

← 1 2 3 4 5 →