Cell spheroids: the new frontiers in in vitro models for cancer drug validation

被引：95

作者：

Chatzinikolaidou, Maria ^{[1
]}

机构：

[1] Univ Crete, Dept Mat Sci & Technol, POB 2208, Herakio 71003, Greece

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 09期

关键词：

3-DIMENSIONAL TUMOR SPHEROIDS; ADVANCED SOLID MALIGNANCIES; MULTICELLULAR SPHEROIDS; BREAST-CANCER; PHASE-I; ANTICANCER THERAPEUTICS; CULTURE; MICROENVIRONMENT; VIVO; HETEROGENEITY;

D O I：

10.1016/j.drudis.2016.06.024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During the past decades, evaluation of anticancer drugs utilizing 2D cell cultures has been in common usage. In contrast to 2D cell cultures however, which lack many characteristics of the complex in vivo situation, 3D cell or tissue culture systems, such as cellular spheroids, better mimic the crucial tumor tissue properties and the microenvironment, and are thus more appropriate for the evaluation of pharmaceutical candidates. Taking the characteristics of the tumor microenvironment into consideration, crucial aspects and recent advances related to cell spheroids in the validation of anticancer drugs are discussed here.

引用

页码：1553 / 1560

页数：8

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