Synthesis, Crystal Structure, and DNA Binding Studies of the 3-(2-(2-Hydroxybenzylidene)Hydrazinyl)Quinoxalin-2(1H)-One

被引：3

作者：

Sukanya, P. ^{[1
]}

Reddy, Ch Venkata Ramana ^{[1
]}

Bhargavi, G. ^{[2
]}

机构：

[1] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad 500085, India

[2] Univ Hyderabad, Sch Chem, Hyderabad 500046, India

来源：

CRYSTALLOGRAPHY REPORTS | 2020年 / 65卷 / 01期

关键词：

TRANSITION-METAL-COMPLEXES; QUINOXALINE; DERIVATIVES; ACID; LIGANDS; COPPER;

D O I：

10.1134/S1063774520010253

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The Schiff base, 3-(2-(2-hydroxybenzylidene)hydrazinyl)quinoxalin-2(1H)-one has been synthesized by condensation of 3-hydrazinyl quinoxalin-2(1H)-one and salicylaldehyde and characterized by infrared and ultraviolet-visible spectroscopy, H-1 NMR, mass spectrometry, elemental analysis, and single crystal X-ray diffraction. The compound crystallizes in the monoclinic system in the space group P2(1)/n with the unit cell parameters a = 5.8619(15) angstrom, b = 24.119(6) angstrom, c = 12.753(4) angstrom, beta = 100.184(9)degrees, Z = 4. The crystal structure is found to be stabilized through inter-molecular hydrogen bonds. The interaction of the compound with Calf Thymus DNA was investigated by ultraviolet spectroscopy, which indicated intercalative mode of binding.

引用

页码：72 / 77

页数：6

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