The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology

被引:8
作者
Foster, Cerrone R. [1 ]
Satomi, Shiho [2 ,3 ]
Kato, Yuko [2 ,3 ,4 ]
Patel, Hemal H. [2 ,3 ]
机构
[1] East Tennessee State Univ, Dept Biol Sci, Johnson City, TN USA
[2] VA San Diego Healthcare Syst, San Diego, CA 92161 USA
[3] Univ Calif San Diego, Dept Anesthesiol, La Jolla, CA 92093 USA
[4] Tokyo Med & Dent Univ, Dept Immunopathol, Grad Sch Med & Dent Sci, Tokyo, Japan
基金
美国国家卫生研究院;
关键词
ALPHA-2-MACROGLOBULIN-METHYLAMINE UNDERGO ENDOCYTOSIS; CARDIAC-SPECIFIC OVEREXPRESSION; PROTEIN-KINASE-C; SCAFFOLDING DOMAIN; INSULIN-RECEPTOR; PLASMA-MEMBRANE; S-NITROSYLATION; LIPID RAFTS; DIFFERENT MECHANISMS; SIGNAL-TRANSDUCTION;
D O I
10.1042/BST20190388
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The plasma membrane is an important cellular organelle that is often overlooked in terms of a primary factor in regulating physiology and pathophysiology. There is emerging evidence to suggest that the plasma membrane serves a greater purpose than a simple barrier or transporter of ions. New paradigms suggest that the membrane serves as a critical bridge to connect extracellular to intracellular communication particularly to regulate energy and metabolism by forming physical and biochemical associations with intracellular organelles. This review will focus on the relationship of a particular membrane microdomain - caveolae - with mitochondria and the particular implication of this to physiology and pathophysiology.
引用
收藏
页码:165 / 177
页数:13
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