Health-related quality of life and neuropathic pain in sickle cell disease in Jamaica

Background: Health related quality of Life (HRQOL) is an important consideration when managing chronic diseases, like sickle cell disease (SCD). Assessment of neuropathic pain (NP) and its association with HRQOL in SCD are rarely reported. Objectives: To examine the prevalence of NP and its association with HRQOL in adult Jamaicans with SCD. Methods: Adult SCD patients were recruited consecutively and data were collected on sociodemographics, NP using Douleur Neuropathique 4 (DN4), and HRQOL using the Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me). Means, medians, t-tests, ANOVA tests, Wilcoxon Rank-sum tests, Kruskal-Wallis tests, Pearson's correlation and multivariate linear regression analyses were performed using STATA 14.2. Results: There were 236 respondents, with 56.8% female, mean age 33.2 years (SD: 11.6; range: 18e67 years), and 75% had homozygous SS genotype. NP was likely present in 26.7% of the population. The standardized ASCQ-Me (mean +/- SD; ordered from lowest to best HRQOL domain scores) were: emotional impact 53.3 +/- 10.1; sleep impact 56.1 +/- 9.7; social function 57.7 +/- 10.6; pain impact 58.6 +/- 7.8; and stiffness impact 61.0 +/- 7.3. On multivariate analyses, NP significantly reduced emotional and social functioning and worsened sleep and stiffness. Higher acute pain scores significantly worsened all HRQOL domains, while higher disease severity worsened all except stiffness. Obesity was associated with worse sleep and greater stiffness. Females with leg ulcers reported lower social functioning and unemployed females had greater pain impact. Conclusions: NP is increasingly prevalent in SCD and worsens HRQOL. Gender specific studies are needed to understand the significantly poorer HRQOL in women. (c) 2021 Elsevier Inc. All rights reserved.