Is Testicular Germ Cell Cancer Estrogen Dependent? The Role of Endocrine Disrupting Chemicals

被引：21

作者：

Fenichel, Patrick ^{[1
,2
]}

Chevalier, Nicolas ^{[1
,2
]}

机构：

[1] Univ Cote Azur, CHU Nice, Serv Endocrinol Diabetol & Med Reprod, Hop Archet, F-06202 Nice 3, France

[2] Univ Cote Azur, Ctr Hosp Univ Nice, INSERM, U1065,UNS,Ctr Mediterraneen Med Mol,Equipe 5, F-06202 Nice 3, France

来源：

ENDOCRINOLOGY | 2019年 / 160卷 / 12期

关键词：

CARCINOMA-IN-SITU; RECEPTOR-BETA; DYSGENESIS SYNDROME; EXPRESSION PATTERN; ANDROGEN RECEPTOR; BREAST-CANCER; HUMAN TESTIS; PROTEIN; GPR30; ALPHA;

D O I：

10.1210/en.2019-00486

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Testicular germ cell cancer (TGCC) is the most frequent cancer of the young male, with an increasing incidence worldwide. The pathogenesis and reasons for this increase remain unknown. However, epidemiological and experimental data have suggested that, similar to genital malformations and sperm impairment, it could result from the interaction of genetic and environmental factors including fetal exposure to endocrine-disrupting chemicals (EDCs) with estrogenic effects. In this review, we analyze the expression of classic and nonclassic estrogen receptors by TGCC cells, the way they may influence germ cell proliferation induced by EDCs, and discuss how this estrogen dependency supports the developmental and environmental hypothesis.

引用

页码：2981 / 2989

页数：9

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