Delayed Gastric Emptying in Patients with Prader Willi Syndrome

被引：21
作者：
Arenz, T. [2 ]
Schwarzer, A. [1 ]
Pfluger, Th [3 ]
Koletzko, S. [1 ]
Schmidt, H. [1 ]
机构：
[1] Univ Munich, Dr von Haunersches Kinderspital, D-80539 Munich, Germany
[2] Univ Bern, Childrens Hosp, Inselspital, CH-3012 Bern, Switzerland
[3] Univ Munich, Dept Nucl Med, D-80539 Munich, Germany
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2010年 / 23卷 / 09期
关键词：
Prader-Willi Syndrome; gastric emptying; gastric rupture; NECROSIS;
D O I：
10.1515/jpem.2010.140
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: A 15 year old girl with Prader-Willi Syndrome (PWS) died of gastric rupture. Systematic literature research revealed seven case reports of PWS patients with acute gastric dilatation, two had a lethal course. The objective of this study was to determine if delayed gastric emptying in PWS patients might contribute to gastric dilatation. Methods: Gastric emptying was measured in eight patients with PWS by nucleotid scintigraphy after a standardized test meal. Results: Median age was 17.8 years (range 10.1-19.5). Median BMI of the male patients was 29.5 (range 18.4-34.8), of the female patients 28 (range 20.0-44.8). Half time of gastric emptying was delayed in five of the eight patients (median 78.5 minutes, range 59-134). Conclusion: Scintigraphic measurement of gastric emptying in eight PWS patients revealed delay in comparison to normal values. This might be a risk factor for gastric dilatation and rupture in patients with PWS.
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收藏
页码：867 / 871
页数：5
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