PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity

被引:8
作者
Canto, Patricia [1 ,2 ]
Benitez Granados, Jesus [1 ]
Feria-Bernal, Guillermo [3 ]
Mauricio Coral-Vazquez, Ramon [4 ,5 ]
Garcia-Garcia, Eduardo [2 ]
Elena Tejeda, Maria [1 ]
Tapia, Andre [1 ]
Rojano-Mejia, David [6 ]
Pablo Mendez, Juan [1 ,2 ]
机构
[1] Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Obesidad, Mexico City, DF, Mexico
[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Clin Obesidad, Mexico City, DF, Mexico
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Urol, Mexico City, DF, Mexico
[4] Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City, DF, Mexico
[5] Inst Seguridad & Serv Sociales Trabajadores Estad, Subdirecc Ensenanza & Invest, Ctr Med Nacl Noviembre 20, Mexico City, DF, Mexico
[6] Inst Mexicano Seguro Social, Hosp Traumatol & Ortopedia Lomas Verdes, UMAE, Unidad Med Fis & Rehabil Ctr, Mexico City, DF, Mexico
关键词
Aggressive prostate cancer; overweight; obesity; polymorphisms; PPARGC1A; ADIPOQ; ACTIVATED RECEPTOR-GAMMA; BODY-MASS INDEX; HUNTINGTON DISEASE; ADIPONECTIN LEVELS; ANTITUMOR-ACTIVITY; GENE VARIANTS; PGC-1-ALPHA; POPULATION; ONSET; RISK;
D O I
10.3233/CBM-160467
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Obesity constitutes a risk factor for the development of aggressive forms of prostate cancer. It has been proposed, that prostate cancer has a genetic predisposition and that PPARGC1A and ADIPOQ polymorphisms play a role in the development of this condition. OBJECTIVE: To analyse the association of two PPARGC1A and ADIPOQ polymorphisms as well as their haplotypes, with the development of aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. SUBJECTS AND METHODS: Two hundred fifty seven men with prostate cancer of Mexican-Mestizo origin were included. Body mass index (BMI) was determined and the degree of prostate cancer aggressiveness by the D'Amico classification. DNA was obtained. Rs7665116 and rs2970870 of PPARGC1A, and rs266729 and rs1501299 of ADIPOQ were studied by real-time PCR allelic discrimination. Pairwise linkage disequilibrium, between single nucleotide polymorphisms was calculated and haplotype analysis was performed. RESULTS: A higher-risk (D'Amico classification) was observed in 21.8% of patients. An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented. CONCLUSIONS: This is the first study regarding the relationship of PPARGC1A and ADIPOQ polymorphisms, and the aggressiveness of prostate cancer in men with overweight or obesity.
引用
收藏
页码:297 / 303
页数:7
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