Three antibacterial naphthoquinone analogues from cultured mycobiont of lichen Astrothelium sp

被引：12

作者：

Sun, Li Yan ^{[2
,3
]}

Liu, Zhen Liang ^{[1
]}

Zhang, Tao ^{[4
]}

Niu, Shu Bin ^{[4
]}

Zhao, Zun Tian ^{[3
]}

机构：

[1] Taishan Med Univ, Coll Chem & Chem Engn, Tai An 271016, Shandong, Peoples R China

[2] Taishan Med Univ, Coll Pharmacol, Tai An 271016, Shandong, Peoples R China

[3] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China

[4] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100101, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Astrothelium sp; Lichen; Mycobiont; 7-Hydroxyl-8-methoxyltrypethelone;

D O I：

10.1016/j.cclet.2010.03.024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp. The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures. Compound 1 displayed significant antibacterial activity against Bacillus subtilis (ATCC 6633), and showed modest antibacterial activity against Staphylococcus aureus col (MRSA) (CGMCC 1.2465), while compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E (CGMCC 1.2135) and S. aureus col (MRSA) (CGMCC 1.2465). (C) 2010 Zun Tian Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：842 / 845

页数：4

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