Biointerfaces Mediated by Molecular Bonds: Cohesive Behaviors

被引:5
作者
Lin, Ji [1 ]
Qian, Jin [2 ]
Yin, Jun [3 ]
Lin, Yuan [4 ]
机构
[1] Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Key Lab Soft Machines & Smart Devices Zhejiang Pr, Soft Matter Res Ctr, Dept Engn Mech, Hangzhou 310027, Zhejiang, Peoples R China
[3] Zhejiang Univ, Coll Mech Engn, Hangzhou 310027, Zhejiang, Peoples R China
[4] Univ Hong Kong, Dept Mech Engn, Hong Kong, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
Cohesive law; interface; molecular bond; rate dependence; hysteresis; CRACK-GROWTH; ADHESION; FORCE; DYNAMICS; SEPARATION; INTERFACE; LIFETIME; SHAPE; LAW; STRENGTH;
D O I
10.1142/S175882511650040X
中图分类号
O3 [力学];
学科分类号
08 ; 0801 ;
摘要
We investigate the cohesive response of biointerfaces mediated by noncovalent receptor-ligand bonding under monotonic, cyclic or other types of loading. By examining the spatiotemporal evolution of the state probability distribution that describes the collective association and dissociation kinetics of interfacial bonds, we show that such interfaces resist the imposed surface separation in a strongly rate-dependent manner. Remarkable hysteresis is exhibited when the interfaces are exposed to single stretching and relaxation cycles at high loading rates, and this hysteretic response shifts in consecutive multiple cycles. There generally exists an optimal ramping velocity that gives rise to the maximum energy dissipation at the interfaces. These results should be useful in understanding the cell-matrix adhesion and de-adhesion phenomena under dynamic and repetitive forces, as well as the adhesion-mediated cellular behaviors such as migration and reorientation.
引用
收藏
页数:15
相关论文
共 48 条
[1]  
Alberts B., 2002, Molecular Biology of the Cell. (4th edition), V4th ed
[2]   Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension [J].
Aratyn-Schaus, Yvonne ;
Gardel, Margaret L. .
CURRENT BIOLOGY, 2010, 20 (13) :1145-1153
[3]  
Barenblatt G.I., 1962, The mathematical theory of equilibrium cracks in brittle fracture, V7, P55, DOI [10.1016/S0065-2156, DOI 10.1016/S0065-2156, DOI 10.1016/S0065-2156(08)70121-2]
[4]  
BELL GI, 1978, SCIENCE, V200, P618, DOI 10.1126/science.347575
[5]   Traction Dynamics of Filopodia on Compliant Substrates [J].
Chan, Clarence E. ;
Odde, David J. .
SCIENCE, 2008, 322 (5908) :1687-1691
[6]   Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells [J].
Chen, Wei ;
Lou, Jizhong ;
Evans, Evan A. ;
Zhu, Cheng .
JOURNAL OF CELL BIOLOGY, 2012, 199 (03) :497-512
[7]   A Viscoelastic Model for the Rate Effect in Transfer Printing [J].
Cheng, H. ;
Li, M. ;
Wu, J. ;
Carlson, A. ;
Kim, S. ;
Huang, Y. ;
Kang, Z. ;
Hwang, K. -C. ;
Rogers, J. A. .
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME, 2013, 80 (04)
[8]   Theory, analysis, and interpretation of single-molecule force spectroscopy experiments [J].
Dudko, Olga K. ;
Hummer, Gerhard ;
Szabo, Attila .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) :15755-15760
[9]   YIELDING OF STEEL SHEETS CONTAINING SLITS [J].
DUGDALE, DS .
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 1960, 8 (02) :100-104
[10]   Stability of adhesion clusters under constant force [J].
Erdmann, T ;
Schwarz, US .
PHYSICAL REVIEW LETTERS, 2004, 92 (10) :108102-1