Late blight, the world's oldest known potato disease, has received fresh attention. Due to changes in the global population structure of the fungus responsible, the rapid expansion of potato production in developing countries, and growing environmental concerns, the burden of late blight is growing. At the same time, new biotechnological means are emerging that may provide a more efficient disease control in the future. Due to these changes, late blight was recently defined as a top priority at the International Potato Centre.