Synthesis and Crystal Structure Characterization of (1R,2R,3R,5S)-3-(3-chlorophenyl)-1-hydroxy-2-methyl-6-phenyl-8-oxa-6-azabicyclo[3.2.1]octan-7-one

被引：0

作者：

Wu, Chao ^{[1
]}

Guo, Yan-Jun ^{[1
]}

Zhang, Xiao-Long ^{[1
]}

Xia, Ai-Bao ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou, Zhejiang, Peoples R China

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2015年 / 607卷 / 01期

关键词：

chirality; single crystal; Bicyclic lactam; X-ray diffraction;

D O I：

10.1080/15421406.2014.928446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, (1R,2R,3R,5S)-3-(3-chlorophenyl)-1-hydroxy-2-methyl-6-phenyl-8-oxa-6-azabicyclo[3.2.1]octan-7-one, was synthesized and characterized by H-1 and C-13 NMR and HRMS spectroscopy. Its absolute molecular configuration was investigated by X-ray crystallography. The crystal structure analysis revealed that the structure exhibits intermolecular hydrogen bonds of the type O-H horizontal ellipsis O. The methyl group and chlorophenyl group are located in the cis configuration. The conformation is stabilized by weak intermolecular C-H... O interactions.

引用

页码：215 / 222

页数：8

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