Intracranial Carotid Artery Atherosclerosis Prevalence and Risk Factors in the General Population

被引:147
作者
Bos, Daniel [1 ]
van der Rijk, Maggee J. M. [1 ]
Geeraedts, Tychon E. A. [1 ]
Hofman, Albert
Krestin, Gabriel P. [1 ]
Witteman, Jacqueline C. M.
van der Lugt, Aad [1 ]
Ikram, M. Arfan [1 ]
Vernooij, Meike W. [1 ]
机构
[1] Erasmus MC, Dept Radiol, NL-3000 CA Rotterdam, Netherlands
关键词
intracranial carotid artery; arterial calcification; atherosclerosis; CT; prevalence; risk factors; COMPUTED-TOMOGRAPHY; AORTIC-ARCH; CALCIFIED ATHEROSCLEROSIS; CORONARY; CALCIFICATION; DISEASE; ASSOCIATION; ROTTERDAM; STROKE; BURDEN;
D O I
10.1161/STROKEAHA.111.648667
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Intracranial atherosclerosis is worldwide one of the leading causes of stroke. However, surprisingly little is known about its prevalence and risk factors in a community-dwelling population of white descent. In this study, we determined the prevalence and investigated risk factors of intracranial internal carotid artery calcification (ICAC) as a marker of intracranial atherosclerosis. Methods-To quantify the volume of ICAC, 2495 participants (mean age, 69.6 years) from the population-based Rotterdam Study underwent a nonenhanced computed tomography of the intracranial internal carotid arteries. We calculated the prevalence of ICAC. Next, we defined sex-specific quartiles and defined the upper quartile as severe ICAC. Risk factors of ICAC were investigated by linear and logistic multivariate modeling and were stratified by sex. Results-The overall prevalence of ICAC was 82.2%. The median volume of ICAC was 44 mm(3) and was larger in men. Age was independently associated with ICAC in both men and women. In men, excessive alcohol intake and smoking (OR, 1.74 [95% CI, 1.28-2.37] and 1.72 [95% CI, 1.10-2.70]) were strong risk factors of ICAC, whereas diabetes and hypertension were in women (OR, 2.02 [95% CI, 1.29-3.17] and 1.79 [95% CI, 1.20-2.68]). A low high-density-lipoprotein concentration was not associated with ICAC. Conclusions-ICAC is highly prevalent and occurs in over 80% of older, white persons. Conventional cardiovascular risk factors are associated with ICAC, but risk factor profiles differ between men and women. (Stroke. 2012;43:1878-1884.)
引用
收藏
页码:1878 / 1884
页数:7
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