Facile Access to Chiral Ketones through Metal-Free Oxidative C?C Bond Cleavage of Aldehydes by O2

被引：64

作者：

Tiwari, Bhoopendra ^{[1
]}

Zhang, Junmin ^{[1
]}

Chi, Yonggui Robin ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

C?C cleavage; enamines; ketones; oxygen; synthetic methods; CARBON-CARBON BOND; INTERMOLECULAR STETTER REACTION; ASYMMETRIC ALPHA-AMINATION; CROSS-COUPLING REACTIONS; N-BOC-IMINES; MOLECULAR-OXYGEN; BETA; BETA-DISUBSTITUTED ENAMINES; MANNICH REACTION; NITROALKENES; CHEMISTRY;

D O I：

10.1002/anie.201107473

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Giving the metal the boot: The title reaction provides facile access to functionalized chiral ketones from chiral α,α′-disubstituted aldehydes in the presence of molecular oxygen (see scheme). The C-C bond-cleavage approach offers an alternative or better method relative to the typical bond-forming strategies used in synthesizing chiral ketones. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1911 / 1914

页数：4

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