Macrophage migration inhibitory factor in acute kidneyinjury

被引：4

作者：

Du, Yiwei ^{[1
]}

Hao, Hao ^{[2
]}

Ma, Heng ^{[2
]}

Liu, Hongbao ^{[1
]}

机构：

[1] Air Force Mil Med Univ, Fourth Mil Med Univ, Tangdu Hosp, Dept Nephrol, Xian, Peoples R China

[2] Air Force Mil Med Univ, Fourth Mil Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Xian, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

acute kidney injury; antioxidant; macrophage migration inhibitory factor; proinflammatory factor; renal tubular epithelial cell; ACTIVATED PROTEIN-KINASE; CELL-CYCLE ARREST; FACTOR MIF; INJURY; EXPRESSION; FIBROSIS; SUSCEPTIBILITY; INFLAMMATION; REGENERATION; SECRETION;

D O I：

10.3389/fphys.2022.945827

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis, which lacks early biomarkers and targeted therapy. Recently, macrophage migration inhibitory factor (MIF) family protein have received increasing attention owing to its pleiotropic protein molecule character in acute kidney injury, where it performed a dual role in the pathological process. macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 are released into the peripheral circulation when Acute kidney injury occurs and interact with various cellular pathways. On the one hand, macrophage migration inhibitory factor exerts a protective effect in anti-oxidation and macrophage migration inhibitory factor-2 promotes cell proliferation and ameliorates renal fibrosis. On the other hand, macrophage migration inhibitory factor aggravates renal injury as an upstream inflammation factor. Herein, we provide an overview on the biological role and possible mechanisms of macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 in the process of Acute kidney injury and the clinical application prospects of macrophage migration inhibitory factor family proteins as a potential therapeutic target.

引用

页数：12

共 114 条

[1] ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis [J].

Al-Abed, Y ;

Dabideen, D ;

Aljabari, B ;

Valster, A ;

Messmer, D ;

Ochani, M ;

Tanovic, M ;

Ochani, K ;

Bacher, M ;

Nicoletti, F ;

Metz, C ;

Pavlov, VA ;

Miller, EJ ;

Tracey, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (44) :36541-36544

[2] MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis [J].

Alampour-Rajabi, Setareh ;

El Bounkari, Omar ;

Rot, Antal ;

Mueller-Newen, Gerhard ;

Bachelerie, Francoise ;

Gawaz, Meinrad ;

Weber, Christian ;

Schober, Andreas ;

Bernhagen, Juergen .

FASEB JOURNAL, 2015, 29 (11) :4497-4511

[3] Functional MIF promoter haplotypes modulate Th17-related cytokine expression in peripheral blood mononuclear cells from control subjects and rheumatoid arthritis patients [J].

Alexis Hernandez-Palma, Luis ;

Garcia-Arellano, Samuel ;

Bucala, Richard ;

Anais Llamas-Covarrubias, Mara ;

De la Cruz-Mosso, Ulises ;

Oregon-Romero, Edith ;

Cerpa-Cruz, Sergio ;

Parra-Rojas, Isela ;

Plascencia-Hernandez, Arturo ;

Francisco Munoz-Valle, Jose .

CYTOKINE, 2019, 115 :89-96

[4] TheMacrophage Migration Inhibitory Factor(MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery [J].

Averdunk, Luisa ;

Bernhagen, Juergen ;

Fehnle, Karl ;

Surowy, Harald ;

Luedecke, Hermann-Josef ;

Mucha, Soeren ;

Meybohm, Patrick ;

Wieczorek, Dagmar ;

Leng, Lin ;

Marx, Gernot ;

Leaf, David E. ;

Zarbock, Alexander ;

Zacharowski, Kai ;

Bucala, Richard ;

Stoppe, Christian .

JOURNAL OF CLINICAL MEDICINE, 2020, 9 (09) :1-18

[5] D-dopachrome tautomerase predicts outcome but not the development of acute kidney injury after orthotopic liver transplantation [J].

Baron-Stefaniak, Joanna ;

Schiefer, Judith ;

Lichtenegger, Paul ;

Miller, Edmund J. ;

Berlakovich, Gabriela A. ;

Faybik, Peter ;

Baron, David M. .

HPB, 2019, 21 (04) :465-472

[6] Comparison of macrophage migration inhibitory factor and neutrophil gelatinase-associated lipocalin-2 to predict acute kidney injury after liver transplantation: An observational pilot study [J].

Baron-Stefaniak, Joanna ;

Schiefer, Judith ;

Miller, Edmund J. ;

Berlakovich, Gabriela A. ;

Baron, David M. ;

Faybik, Peter .

PLOS ONE, 2017, 12 (08)

[7] Acute kidney injury [J].

Bellomo, Rinaldo ;

Kellum, John A. ;

Ronco, Claudio .

LANCET, 2012, 380 (9843) :756-766

[8] MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment [J].

Bernhagen, Juergen ;

Krohn, Regina ;

Lue, Hongqi ;

Gregory, Julia L. ;

Zernecke, Alma ;

Koenen, Rory R. ;

Dewor, Manfred ;

Georgiev, Ivan ;

Schober, Andreas ;

Leng, Lin ;

Kooistra, Teake ;

Fingerle-Rowson, Guenter ;

Ghezzi, Pietro ;

Kleemann, Robert ;

McColl, Shaun R. ;

Bucala, Richard ;

Hickey, Michael J. ;

Weber, Christian .

NATURE MEDICINE, 2007, 13 (05) :587-596

[9] Prerenal acute kidney injury-still a relevant term in modern clinical practice? [J].

Bonavia, Anthony ;

Vece, Gregory ;

Karamchandani, Kunal .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2021, 36 (09) :1570-1577

[10] Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis [J].

Bonventre, Joseph V. .

KIDNEY INTERNATIONAL SUPPLEMENTS, 2014, 4 (01) :39-44

← 1 2 3 4 5 6 7 8 9 10 →