Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

被引：80

作者：

Gremaud, Ludovic ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

amino acids; asymmetric catalysis; copper; enantioselectivity; synthetic methods; CYCLIC 1,3-DICARBONYL COMPOUNDS; ASYMMETRIC MICHAEL REACTIONS; PRIMARY ALLYLIC ALCOHOLS; KETO ESTERS; TRIALKYLALUMINUM REAGENTS; GRIGNARD-REAGENTS; ACID; 1,4-ADDITION; ENONES; ISOMERIZATION;

D O I：

10.1002/anie.201107324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not a cop out: The copper-catalyzed asymmetric conjugate addition of organometallic reagents to Michael acceptors is an important methodology for forming a C-C bond in an enantioselective manner. Such an addition of Me 3Al to β,γ-unsaturated α-ketoesters is described to proceed in high yield and selectivity. CuTC=copper(I) thiophene-2-carboxylate. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：794 / 797

页数：4

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