Design and optimization of some collagen-minocycline based hydrogels potentially applicable for the treatment of cutaneous wound infections

被引：34

作者：

Ghica, M. V. ^{[1
]}

Albu, M. G.

Leca, M. ^{[2
]}

Popa, L. ^{[1
]}

Moisescu, St. ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Pharm, Phys & Colloidal Chem Dept, Bucharest 020956, Romania

[2] Univ Bucharest, Dept Phys Chem, Fac Chem, Bucharest, Romania

来源：

PHARMAZIE | 2011年 / 66卷 / 11期

关键词：

RESPONSE-SURFACE METHODOLOGY; IN-VITRO RELEASE; GEL FORMULATIONS; DRUG-RELEASE; NANOPARTICLES; EXTRACTION; PARAMETERS; DELIVERY; SYSTEMS;

D O I：

10.1691/ph.2011.1061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Topical delivery systems for the treatment of different infected cutaneous wounds based on natural biopolymers are widely studied. The development of some topical hydrogels with type I collagen and minocycline by the experimental design technique, based on response surface methodology and Taguchi's approach, and the evaluation of their kinetic properties is presented. The concentrations of polymer, drug and cross-linking agent were selected as independent variables for the face centered composite design and low, medium and high concentration as variation levels for each factor. Minocycline kinetic release was investigated using a modified Franz diffusion cell. The drug release followed the Higuchi model. Three formulations having optimal minocycline release profiles were selected. They can be used as potential drug topical release systems for the treatment of infected cutaneous tissue.

引用

页码：853 / 861

页数：9

共 47 条

[1] Optimizing power consumption for CNC turned parts using response surface methodology and Taguchi's technique - A comparative analysis [J].