Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

被引:33
作者
Bahn, Yong-Sun [1 ]
机构
[1] Yonsei Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
基金
新加坡国家研究基金会;
关键词
CANDIDA-ALBICANS; NRG1; PATHOGENESIS; NETWORKS; PATHWAY; GENES;
D O I
10.1371/journal.ppat.1004936
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页数:7
相关论文
共 34 条
[1]   Inhibition of transcription factors with small organic molecules [J].
Berg, Thorsten .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2008, 12 (04) :464-471
[2]   Hidden Killers: Human Fungal Infections [J].
Brown, Gordon D. ;
Denning, David W. ;
Gow, Neil A. R. ;
Levitz, Stuart M. ;
Netea, Mihai G. ;
White, Theodore C. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (165)
[3]   Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformans [J].
Cheon, Seon Ah ;
Jung, Kwang-Woo ;
Chen, Ying-Lien ;
Heitman, Joseph ;
Bahn, Yong-Sun ;
Kang, Hyun Ah .
PLOS PATHOGENS, 2011, 7 (08)
[4]   A Major Role for Capsule-Independent Phagocytosis-Inhibitory Mechanisms in Mammalian Infection by Cryptococcus neoformans [J].
Chun, Cheryl D. ;
Brown, Jessica C. S. ;
Madhani, Hiten D. .
CELL HOST & MICROBE, 2011, 9 (03) :243-251
[5]   BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence [J].
Cleary, Ian A. ;
Lazzell, Anna L. ;
Monteagudo, Carlos ;
Thomas, Derek P. ;
Saville, Stephen P. .
MOLECULAR MICROBIOLOGY, 2012, 85 (03) :557-573
[6]   Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans [J].
Cramer, Kari L. ;
Gerrald, Quincy D. ;
Nichols, Connie B. ;
Price, Michael S. ;
Alspaugh, J. Andrew .
EUKARYOTIC CELL, 2006, 5 (07) :1147-1156
[7]   Candida albicans RIM101 pH response pathway is required for host-pathogen interactions [J].
Davis, D ;
Edwards, JE ;
Mitchell, AP ;
Ibrahim, AS .
INFECTION AND IMMUNITY, 2000, 68 (10) :5953-5959
[8]   Roles of Candida albicans Gat2, a GATA-Type Zinc Finger Transcription Factor, in Biofilm Formation, Filamentous Growth and Virulence [J].
Du, Han ;
Guan, Guobo ;
Xie, Jing ;
Sun, Yuan ;
Tong, Yaojun ;
Zhang, Lixin ;
Huang, Guanghua .
PLOS ONE, 2012, 7 (01)
[9]   p53 as a target for the treatment of cancer [J].
Duffy, Michael J. ;
Synnott, Naoise C. ;
McGowan, Patricia M. ;
Crown, John ;
O'Connor, Darran ;
Gallagher, William M. .
CANCER TREATMENT REVIEWS, 2014, 40 (10) :1153-1160
[10]   Zap1 Control of Cell-Cell Signaling in Candida albicans Biofilms [J].
Ganguly, Shantanu ;
Bishop, Andrew C. ;
Xu, Wenjie ;
Ghosh, Suman ;
Nickerson, Kenneth W. ;
Lanni, Frederick ;
Patton-Vogt, Jana ;
Mitchell, Aaron P. .
EUKARYOTIC CELL, 2011, 10 (11) :1448-1454