Dynamics of epidemic spreading model with drug-resistant variation on scale-free networks

Considering the influence of the virus' drug-resistant variation, a novel SIVRS (susceptible-infected-variant-recovered-susceptible) epidemic spreading model with variation characteristic on scale-free networks is proposed in this paper. By using the mean-field theory, the spreading dynamics of the model is analyzed in detail. Then, the basic reproductive number R-0 and equilibriums are derived. Studies show that the existence of disease free equilibrium is determined by the basic reproductive number R-0. The relationships between the basic reproductive number R-0, the variation characteristic and the topology of the underlying networks are studied in detail. Furthermore, our studies prove the global stability of the disease-free equilibrium, the permanence of epidemic and the global attractivity of endemic equilibrium. Numerical simulations are performed to confirm the analytical results. (C) 2017 Elsevier B.V. All rights reserved.