Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC

被引：5

作者：

Bidló-Iglóy, M ^{[1
]}

Mátyus, P ^{[1
]}

机构：

[1] Inst Drug Res, H-1325 Budapest, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 19卷 / 3-4期

关键词：

pyridazinone derivatives; Chiralcel columns; chiral HPLC;

D O I：

10.1016/S0731-7085(98)00243-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several 4,5-disubstituted 3(2H)-pyridazinone derivatives containing 2-hydroxymethylpyrrolidino moiety as a chiral building block were synthetized. Separation of enantiomers was carried out by chiral HPLC on Chiralcel OJ and OF columns. Mobile phases consisted of hexane, ethanol and 2-propanol. Chiralcel OJ column was capable of separating most of the enantiomeric pairs. For one type of compound, Chiralcel OF column was used for separation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：487 / 490

页数：4