Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft

被引：0

作者：

Zhu, Hong ^{[1
]}

Guo, Yong-Zhang ^{[1
]}

Zhang, Jie ^{[1
]}

Hu, Ming-Dao ^{[1
]}

Tang, Ji-Hong ^{[1
]}

Tian, Da-Guang ^{[1
]}

Yong-Jun, A. ^{[1
]}

Sun, Feng ^{[1
]}

Wei, Xiao-Ping ^{[1
]}

机构：

[1] Kunming Med Coll, Affiliated Hosp 2, Div Hepatobiliary Dept 1, Kunming 650101, Peoples R China

来源：

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL | 2007年 / 6卷 / 04期

关键词：

liver transplantation; hepatic nerve; Kupffer cells; reperfusion injury; adhesion molecule;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND: The non-function and dysfunction of primary liver graft likely involves dependence on Kupffer cells and hepatic innervation. The present experiment was designed to study the expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) mRNA in liver graft and to elucidate the role of Kupffer cells and the sympathetic nerve of the liver in down-regulating this expression. METHODS: Donor rats were given hexamethonium, a sympathetic ganglionic blocking agent, and/or gadolinium chloride, an inhibitor of Kupffer cells. Then the changes of graft P-selectin and ICAM-1 mRNA expression were measured after liver transplantation. RESULTS: The expressions of P-selectin and ICAM-1 mRNA were increased after liver transplantation, and down-regulated by liver denervation and elimination of Kupffer cells. CONCLUSIONS: Live donor denervation and elimination of Kupffer cells down-regulated the expressions of P-selectin and ICAM-1 mRNA in grafts. This may decrease graft ischemia/reperfusion injury.

引用

页码：379 / 382

页数：4

共 23 条

[1] ADHESION MOLECULES AND INFLAMMATORY INJURY [J].

ALBELDA, SM ;

SMITH, CW ;

WARD, PA .

FASEB JOURNAL, 1994, 8 (08) :504-512

[2] ET-1 INDUCED ALTERATIONS OF HEPATIC MICROCIRCULATION - SINUSOIDAL AND EXTRASINUSOIDAL SITES OF ACTION [J].

BAUER, M ;

ZHANG, JX ;

BAUER, I ;

CLEMENS, MG .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (01) :G143-G149

[3] KUPFFER CELL ACTIVATION AND ENDOTHELIAL-CELL DAMAGE AFTER STORAGE OF RAT LIVERS - EFFECTS OF REPERFUSION [J].

CALDWELLKENKEL, JC ;

CURRIN, RT ;

TANAKA, Y ;

THURMAN, RG ;

LEMASTERS, JJ .

HEPATOLOGY, 1991, 13 (01) :83-95

[4]

Casillas-Ramirez A, 2006, Gastroenterol Hepatol, V29, P306, DOI 10.1157/13087472

[5] VONWILLEBRAND-FACTOR PROMOTES ENDOTHELIAL-CELL ADHESION VIA AN ARG-GLY-ASP-DEPENDENT MECHANISM [J].

DEJANA, E ;

LAMPUGNANI, MG ;

GIORGI, M ;

GABOLI, M ;

FEDERICI, AB ;

RUGGERI, ZM ;

MARCHISIO, PC .

JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :367-375

[6] COMPLEMENT C5A-MEDIATED MYOCARDIAL-ISCHEMIA AND NEUTROPHIL SEQUESTRATION - 2 INDEPENDENT PHENOMENA [J].

DELBALZO, U ;

ENGLER, RL ;

ITO, BR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (02) :H336-H344

[7] Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1 [J].

Dulkanchainun, TS ;

Goss, JA ;

Imagawa, DK ;

Shaw, GD ;

Anselmo, DM ;

Kaldas, F ;

Wang, T ;

Zhao, DL ;

Busuttil, AA ;

Kato, H ;

Murray, NGB ;

Kupiec-Weglinski, JW ;

Busuttil, RW .

ANNALS OF SURGERY, 1998, 227 (06) :832-839

[8]

Gu XP, 2004, WORLD J GASTROENTERO, V10, P1000

[9] Mechanisms of neutrophil-induced parenchymal cell injury [J].

Jaeschke, H ;

Smith, CW .

JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 61 (06) :647-653

[10] Evaluation of microperfusion disturbances in the transplanted liver after Kupffer cell destruction using GdCl3:: An experimental porcine study [J].

Jahnke, C. ;

Mehrabi, A. ;

Golling, M. ;

Von Frankenberg, M. ;

Kashfi, A. ;

Nentwich, H. ;

Fonouni, H. ;

Nickkholgh, A. ;

Schemmer, P. ;

Gutt, C. N. ;

Weitz, J. ;

Schmidt, J. ;

Gebhard, M. M. ;

Buechler, M. W. ;

Kraus, Th. .

TRANSPLANTATION PROCEEDINGS, 2006, 38 (05) :1588-1595

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