Histochemical demonstration of sialic acids and antimicrobial substances in the porcine anal glands

被引：5

作者：

Nara, Takayuki ^{[1
]}

Yasui, Tadashi ^{[1
]}

Meyer, Wilfried ^{[2
]}

Tsukise, Azuma ^{[1
]}

机构：

[1] Nihon Univ, Coll Bioresource Sci, Dept Vet Anat, Fujisawa, Kanagawa 2528510, Japan

[2] Univ Vet Med Hannover, Inst Anat, D-30173 Hannover, Germany

来源：

ACTA HISTOCHEMICA | 2012年 / 114卷 / 04期

关键词：

Anal glands; Sialic acids; Antimicrobial substances; Histochemistry; Pig; LACTOFERRIN; PEPTIDES; DEFENSE; SUGARS; MUCUS;

D O I：

10.1016/j.acthis.2011.06.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The distribution of sialic acids and antimicrobial products (lysozyme, beta-defensin-1, lactoferrin, IgA) in the anal glands of miniature pig was studied by glycoconjugate histochemistry and immunohistochemistry. The glandular acini of these glands exhibited considerable amounts of sialoglycoconjugates that terminated in Sia alpha 2-6Gal/GalNAc or Sia alpha 2-3Gal1-4GlcNAc, including O-acetylated sialic acids. Additionally, all antimicrobial products examined could be demonstrated in the anal glands, especially in the serous cells. The results obtained are discussed with regard to the functional significance of the anal glands. Our observations corroborated the view that sialic acids closely interact with defense cells and antimicrobial substances in the innate immune response. Therefore, the anal glandular secretions may function as protective agents in order to preserve the integrity of the anal region. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：327 / 333

页数：7

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