Advances in the Synthesis of Natural Products and Medicinally Relevant Molecules from Glycals

被引：6
作者：
Hussain, Nazar [1 ]
Rasool, Faheem [2 ]
Khan, Shahnawaz [3 ]
Saleem, Mohd [4 ]
Maheshwari, Mittali [1 ]
机构：
[1] Banaras Hindu Univ, Dept Med Chem, Varanasi, Uttar Pradesh, India
[2] Govt Coll Women, Dept Chem, Jammu 180001, India
[3] Cent Univ Jammu, Dept Chem, Jammu 180001, India
[4] Govt Postgrad Coll, Dept Chem, Rajouri, India
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 40期
关键词：
Glycals; Natura; Product; TotalSynthesi; Drug; Glycosides; PLATELET-ACTIVATING-FACTOR; CYTOTOXIC 14-MEMBERED MACROLIDES; DIELS-ALDER REACTIONS; 1ST TOTAL-SYNTHESIS; FORMAL SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ANTIFUNGAL ACTIVITY; OLEFIN METATHESIS; ORGANIC-SYNTHESIS;
D O I：
10.1002/slct.202201873
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Glycals have been extensively utilized as a versatile building block in the constructions of C-glycosides, branched sugars, and the total synthesis of natural products and biologically potent molecules. The versatility of glycals can be attributed to their easy availability and the presence of endocyclic ring oxygen in conjugation with the double bond. The inbuilt chirality further enhances its applicability in the chiral pool synthesis of natural products and pharmaceuticals. In this review, we have summarized the development made in the total synthesis of natural products and some medicinally relevant molecules from glycals.
引用
收藏
页数：11
相关论文
共 147 条
  • [1] Mechanistic study of the Mitsunobu reaction
    Ahn, CJ
    Correia, R
    DeShong, P
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (06) : 1751 - 1753
  • [2] Andrea Z., 2013, SYNTHESIS, V45, P625
  • [3] The carbon-Ferrier rearrangement: an approach towards the synthesis of C-glycosides
    Ansari, Alafia Ali
    Lahiri, Rima
    Vankar, Yashwant D.
    [J]. ARKIVOC, 2013, : 316 - 362
  • [4] Synthesis of the JKLM-ring fragment of ciguatoxin
    Baba, T
    Huang, G
    Isobe, M
    [J]. TETRAHEDRON, 2003, 59 (35) : 6851 - 6872
  • [5] PLATELET-ACTIVATING-FACTOR AND POLYUNSATURATED FATTY-ACIDS IN CEREBRAL-ISCHEMIA OR CONVULSIONS - INTRACELLULAR PAF-BINDING SITES AND ACTIVATION OF A FOS/JUN/AP-1 TRANSCRIPTIONAL SIGNALING SYSTEM
    BAZAN, NG
    SQUINTO, SP
    BRAQUET, P
    PANETTA, T
    MARCHESELLI, VL
    [J]. LIPIDS, 1991, 26 (12) : 1236 - 1242
  • [6] Total synthesis of reblastatin: convenient preparation of coupling partners and scaled assembly
    Bian, Chuancai
    Yan, Rui
    Yu, Xiaoming
    [J]. TETRAHEDRON, 2014, 70 (18) : 2982 - 2991
  • [7] A morphable model for the synthesis of 3D faces
    Blanz, V
    Vetter, T
    [J]. SIGGRAPH 99 CONFERENCE PROCEEDINGS, 1999, : 187 - 194
  • [8] THE 1ST EXAMPLE OF A ROBINSON ANNULATION ON A CARBOHYDRATE DERIVATIVE
    BONNERT, RV
    JENKINS, PR
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (01) : 6 - 7
  • [9] An Efficient Formal Synthesis of (-)-Clavosolide A Featuring a "Mismatched" Stereoselective Oxocarbenium Reduction
    Carrick, Jesse D.
    Jennings, Michael P.
    [J]. ORGANIC LETTERS, 2009, 11 (03) : 769 - 772
  • [10] SGLT2 inhibition - a novel strategy for diabetes treatment
    Chao, Edward C.
    Henry, Robert R.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (07) : 551 - 559
12345678910