Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy

被引：106
|
作者：
De Broe, Marc E. [1 ]
机构：
[1] Univ Antwerp, Fac Med, B-2020 Antwerp, Belgium
来源：
KIDNEY INTERNATIONAL | 2012年 / 81卷 / 06期
关键词：
DNA-ADDUCTS; FIBROSIS;
D O I：
10.1038/ki.2011.428
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic tubulointerstitial renal diseases associated with urothelial carcinoma. The clinical expression and pathological lesions observed at different stages of CHN and BEN are strikingly similar. Both have been linked to exposure to aristolochic acid (AA), a powerful nephrotoxin and human carcinogen. Jelakovic et al. present molecular epidemiological evidence relating urothelial carcinoma in patients with BEN to dietary exposure to AA. It is time to abandon the terms 'CHN' and 'BEN' and introduce 'aristolochic acid nephropathy' to cover both clinical conditions. Kidney International (2012) 81, 513-515. doi: 10.1038/ki.2011.428
引用
收藏
页码：513 / 515
页数：3
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