Tacrolimus, a relatively new therapeutic option for patients with corticosteroid-refractory Crohn's disease or ulcerative colitis, is a substrate for the apically directed efflux transporter P-glycoprotein (P-gp). Duodenal biopsy specimens obtained from a patient with corticosteroid-refractory Crohn's disease and with significantly higher-than-average tacrolimus dose requirements were analyzed for P-gp by Western blot. The P-gp content in this patient was more than double that in specimens obtained from 9 of 10 healthy subjects. Elevated intestinal P-gp could have resulted in decreased tacrolimus absorption, thereby leading, to decreased blood concentration and decreased efficacy in this patient. The cause and prevalence of this phenomenon are unknown.
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Faubion, WA
;
Loftus, EV
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Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Loftus, EV
;
Harmsen, WS
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机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Harmsen, WS
;
Zinsmeister, AR
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Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Zinsmeister, AR
;
Sandborn, WJ
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Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Faubion, WA
;
Loftus, EV
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Loftus, EV
;
Harmsen, WS
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Harmsen, WS
;
Zinsmeister, AR
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA
Zinsmeister, AR
;
Sandborn, WJ
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Biostat Sect, Rochester, MN 55905 USA