Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

被引：39

作者：

Kawamura, Shintaro ^{[1
,2
]}

Kawabata, Tatsuya ^{[1
,2
]}

Ishizuka, Kentaro ^{[1
]}

Nakamura, Masaharu ^{[1
,2
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Int Res Ctr Elements Sci IRCELS, Uji, Kyoto 6110011, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Hydrocarbon Chem, Uji, Kyoto 6110011, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 75期

基金：

日本学术振兴会;

关键词：

SECONDARY ALKYL-HALIDES; GRIGNARD-REAGENTS; ORGANIC-SYNTHESIS; SUZUKI REACTIONS; ATE COMPLEXES; HYDROXY-GROUP; REACTIVITY; CHLORIDES; ALKOXIDES; ALCOHOLS;

D O I：

10.1039/c2cc34185a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron-bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction.

引用

页码：9376 / 9378

页数：3

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