Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance

被引：21
作者：
Alame-Emane, A. K. [1 ,2 ]
Xu, P. [3 ,4 ]
Pierre-Audigier, C. [1 ,5 ]
Cadet-Daniel, V. [1 ]
Shen, X. [6 ]
Sraouia, M. [5 ]
Siawaya, J. F. Djoba [2 ]
Takiff, H. [7 ]
Gao, Q. [3 ,4 ]
Gicquel, B. [1 ,8 ]
机构：
[1] Inst Pasteur, Unite Genet Mycobacterienne, F-75015 Paris, France
[2] Natl Lab Publ Hlth, Res & Specialised Diagnost Unit, Libreville, Gabon
[3] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Key Lab Med Mol Virol, Shanghai 200433, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Inst Med Microbiol, Key Lab Med Mol Virol, Shanghai 200433, Peoples R China
[5] Bichat Claude Bernard Hosp, Lab Bacteriol, Paris, France
[6] Shanghai Municipal Ctr Dis Control & Prevent, Dept TB Control, Shanghai, Peoples R China
[7] Inst Venezolano Invest Cient, Ctr Microbiol & Biol Celular, Lab Genet Mol, Caracas, Venezuela
[8] Inst Pasteur Shanghai, Emerging Bacterial Pathogens Lab, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2015年 / 19卷 / 06期
关键词：
tuberculosis; drug resistance; pyrazinamide; PNCA GENE; SUSCEPTIBILITY; IDENTIFICATION; DIAGNOSIS;
D O I：
10.5588/ijtld.14.0768
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
BACKGROUND: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern. OBJECTIVE: To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP). DESIGN: Isolates from two major urban centres Paris (101 strains) and Shanghai (171 strains) were investigated for the association of pncA mutations with resistance to drugs other than PZA. RESULTS: The proportion of pncA mutations found in INH-monoresistant strains was not increased. CONCLUSION: pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
引用
收藏
页码：679 / 684
页数：6
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