Chelation-controlled intermolecular hydroacylation: Direct addition of alkyl aldehydes to functionalized alkenes

被引：123
|
作者：
Willis, MC [1 ]
McNally, SJ
Beswick, PJ
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] GlaxoSmithKline, Med Res Ctr, Neurol Ctr Excellence Drug Discovery, Stevenage SG1 2NY, Herts, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期
关键词：
aldehydes; alkenes; homogeneous catalysis; hydroacylation; rhodium;
D O I：
10.1002/anie.200352751
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R = ester, arnide, imide, sulfone; dppe = 1,2-bis(diphenylphosphanyl)ethane.
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页码：340 / 343
页数：4
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