Quantitative imaging of coronary flows using 3D ultrafast Doppler coronary angiography

被引：13

作者：

Correia, M. ^{[1
]}

Maresca, D. ^{[1
]}

Goudot, G. ^{[1
]}

Villemain, O. ^{[1
]}

Bize, A. ^{[2
,3
,4
]}

Sambin, L. ^{[2
,3
,4
]}

Tanter, M. ^{[1
]}

Ghaleh, B. ^{[2
,3
,4
]}

Pernot, M. ^{[1
]}

机构：

[1] PSL Res Univ, CNRS FRE 2031, ESPCI ParisTech, Phys Med,INSERM U1273, F-75012 Paris, France

[2] INSERM U955, Equipe 03, F-94000 Creteil, France

[3] Univ Paris Est, F-94000 Maisons Alfort, France

[4] Ecole Natl Vet Alfort, F-94000 Maisons Alfort, France

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2020年 / 65卷 / 10期

基金：

欧洲研究理事会;

关键词：

ultrafast ultrasound; volumetric imaging; coronary perfusion; Doppler imaging; VELOCITY; ARTERY; MANAGEMENT;

D O I：

10.1088/1361-6560/ab8d78

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Coronary flow rate remains complex to assess in clinical practice using non-invasive, non-ionizing imaging tools. In this study, we introduce 3D ultrafast Doppler coronary angiography (3D UDCA), an ultrasound-based method to assess coronary blood flows in three-dimensions at high volume-rate and in one single heartbeat. We demonstrate that 3D UDCA can visualize the coronary vasculature with high temporal and spatial resolution and quantify the absolute flow. The feasibility of the technique was demonstrated in an open-chest swine model. The flow rate of the left-anterior descending artery (LAD) assessed by 3D UDCA was reconstructed successfully at the early diastolic and late diastolic phases and was in good agreement with an invasive gold-standard flowmeter during baseline, reactive hyperemia and coronary stenosis (r(2) = 0.84). Finally, we demonstrate that a coronary stenosis on the LAD can be visualized as well as its associated flow acceleration.

引用

页数：9

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