Role of Common blaOXA-24/OXA-40-Carrying Platforms and Plasmids in the Spread of OXA-24/OXA-40 among Acinetobacter Species Clinical Isolates

被引：46
作者：
Grosso, Filipa [1 ]
Quinteira, Sandra [1 ,2 ,3 ]
Poirel, Laurent [4 ]
Novais, Angela [1 ]
Peixe, Luisa [1 ]
机构：
[1] Univ Porto, REQUIMTE, Lab Microbiol, Fac Farm, P-4100 Oporto, Portugal
[2] Ctr Invest Tecnol Saude CITS IPSN CESPU, Vila Nova De Famalicao, Portugal
[3] Ctr Invest Biodiversidade & Recursos Genet CIBIO, Vairao, Portugal
[4] Hop Bicetre, Serv Bacteriol Virol, INSERM, S Paris Med Sch,U914, K Bicetre, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 07期
关键词：
OXA-24; CARBAPENEMASE;
D O I：
10.1128/AAC.06255-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla(OXA-24/40)-carrying plasmids and genetic environments were characterized in representative (n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla(OXA-24/40) within the chromosomes of some isolates, the circulation of common bla(OXA-24/40)-carrying plasmids (30-kb repA_AB; 10-kb aci2) and genetic backbones among Acinetobacter spp. was demonstrated.
引用
收藏
页码：3969 / 3972
页数：4
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