An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy

被引:39
作者
Godin, Biana [1 ]
Driessen, Wouter H. P. [2 ]
Proneth, Bettina [2 ]
Lee, Sei-Young [1 ,4 ]
Srinivasan, Srimeenakshi [1 ]
Rumbaut, Rolando [5 ]
Arap, Wadih [2 ,3 ]
Pasqualini, Renata [2 ,3 ]
Ferrari, Mauro [1 ,6 ,7 ]
Decuzzi, Paolo [1 ,8 ]
机构
[1] Univ Texas Hlth Sci Ctr, Dept Nanomed & Biomed Engn, Houston, TX 77225 USA
[2] Univ Texas MD Anderson Canc Ctr, David H Koch Ctr, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA
[4] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA
[5] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[7] Rice Univ, Dept Biomed Engn, Houston, TX USA
[8] Magna Graecia Univ Catanzaro, Ctr Bionanotechnol & Engn Med, Catanzaro, Italy
来源
TISSUE-SPECIFIC VASCULAR ENDOTHELIAL SIGNALS AND VECTOR TARGETING, PT B | 2010年 / 69卷
关键词
VASCULAR-PERMEABILITY; CHEMOTHERAPEUTIC-AGENTS; MONOCLONAL-ANTIBODIES; GENE DELIVERY; GROWTH-FACTOR; BINDING-SITE; NITRIC-OXIDE; TUMOR-CELLS; SOLID TUMOR; IN-VITRO;
D O I
10.1016/S0065-2660(10)69009-8
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The use of nanoparticles for the early detection, cure, and imaging of diseases has been proved already to have a colossal potential in different biomedical fields, such as oncology and cardiology. A broad spectrum of nanoparticles are currently under development, exhibiting differences in (i) size, ranging from few tens of nanometers to few microns; (ii) shape, from the classical spherical beads to discoidal, hemispherical, cylindrical, and conical; (iii) surface functionalization, with a wide range of electrostatic charges and biomolecule conjugations. Clearly, the library of nanoparticles generated by combining all possible sizes, shapes, and surface physicochemical properties is enormous. With such a complex scenario, an integrated approach is here proposed and described for the rational design of nanoparticle systems (nanovectors) for the intravascular delivery of therapeutic and imaging contrast agents. The proposed integrated approach combines multiscale/multiphysics mathematical models with in vitro assays and in vivo intravital microscopy (IVM) experiments and aims at identifying the optimal combination of size, shape, and surface properties that maximize the nanovectors localization within the diseased microvasculature. (C) 2010, Elsevier Inc.
引用
收藏
页码:31 / 64
页数:34
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