Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

被引：99

作者：

Bag, Partha Pratim ^{[2
]}

Chen, Miles ^{[1
]}

Sun, Changquan Calvin ^{[1
]}

Reddy, C. Malla ^{[2
]}

机构：

[1] Univ Minnesota, Coll Pharm, Dept Pharmaceut, Minneapolis, MN 55455 USA

[2] Indian Inst Sci Educ & Res, Kolkata 741252, W Bengal, India

来源：

CRYSTENGCOMM | 2012年 / 14卷 / 11期

关键词：

TRUE DENSITY; COMPACTION PROPERTIES; PARACETAMOL; POLYMORPHS; CELLULOSE; FORMS;

D O I：

10.1039/c2ce25100k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Powder compaction data of three polymorphic Forms I (shearing), II (bending) and III (brittle) of 6-chloro-2,4-dinitroaniline demonstrates a direct relationship among mechanical properties, crystal structure and tableting behaviour, showing the essence of structure based assessment of mechanical properties of crystals, e. g., for identifying more efficient API formulation and manufacture processes.

引用

页码：3865 / 3867

页数：3

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