Tetra-2,3-pyrazinoporphyrazines with Externally Appended Pyridine Rings. 10. A Water-Soluble Bimetallic (ZnII/PtII) Porphyrazine Hexacation as Potential Plurimodal Agent for Cancer Therapy: Exploring the Behavior as Ligand of Telomeric DNA G-Quadruplex Structures

被引：25

作者：

Manet, Ilse ^{[1
]}

Manoli, Francesco ^{[1
]}

Donzello, Maria Pia ^{[2
]}

Ercolani, Claudio ^{[2
]}

Vittori, Daniela ^{[2
]}

Cellai, Luciano ^{[3
]}

Masi, Annalisa ^{[3
]}

Monti, Sandra ^{[1
]}

机构：

[1] CNR, Ist Sintesi Organ & Fotoreattivita, I-40129 Bologna, Italy

[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] CNR, Ist Cristallog, I-00015 Rome, Italy

来源：

INORGANIC CHEMISTRY | 2011年 / 50卷 / 16期

关键词：

INTRAMOLECULAR G-QUADRUPLEX; CATIONIC PORPHYRINS; SINGLET OXYGEN; TARGETS; FORMS; SEQUENCE; INHIBITION; STABILITY; TOPOLOGY; KINETICS;

D O I：

10.1021/ic200514z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The behavior of a bimetallic water-soluble (Zn-II/Pt-II) porphyrazine hexacation as ligand of G-quadruplex (G4) structures adopted by a human telomeric DNA sequence has been examined with different spectroscopic techniques. In K+ rich solution the hexacationic Zn-II porphyrazine ligand bearing a peripheral cis-platin-like functionality changes the G-quadruplex conformational equilibrium of the human telomeric sequence 5'-d[AGGG(TTAGGG)(3)]-3' and drives it exclusively toward a very stable parallel G4 form in the complex with 2:1 stoichiometry. An increase of the melting temperature of more than 20 degrees C is observed in this complex compared to the G4 alone. On the contrary ligand binding to G-quadruplex of the same telomeric sequence in Na+ rich solution neither markedly influences the predominant basket conformation nor confers increased thermal stability to the G4 structure.

引用

页码：7403 / 7411

页数：9

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