Current and future nanoparticle vaccines for COVID-19

被引：59

作者：

Vu, Mai N. ^{[1
,2
,3
,4
]}

Kelly, Hannah G. ^{[1
,2
]}

Kent, Stephen J. ^{[1
,2
,5
,6
,7
]}

Wheatley, Adam K. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia

[2] Australian Res Council, Ctr Excellence Convergent Bionano Sci & Technol, Parkville, Vic 3052, Australia

[3] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[4] Hanoi Univ Pharm, Dept Pharmaceut, Hanoi 10000, Vietnam

[5] Monash Univ, Alfred Hosp, Melbourne Sexual Hlth Ctr, Melbourne, Vic 3004, Australia

[6] Monash Univ, Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3004, Australia

[7] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia

来源：

EBIOMEDICINE | 2021年 / 74卷

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

nanoparticle vaccine; COVID-19; vaccine; SARS-CoV-2; neutralizing antibody; protein nanoparticle; ACCURATE DESIGN; UNITED-STATES; SARS-COV-2; ADJUVANTS; RESPONSES; RBD;

D O I：

10.1016/j.ebiom.2021.103699

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 has become a major cause of global mortality and driven massive health and economic disruptions. Mass global vaccination offers the most efficient pathway towards ending the pandemic. The development and deployment of first-generation COVID-19 vaccines, encompassing mRNA or viral vectors, has proceeded at a phenomenal pace. Going forward, nanoparticle-based vaccines which deliver SARS-CoV-2 antigens will play an increasing role in extending or improving vaccination outcomes against COVID-19. At present, over 26 nanoparticle vaccine candidates have advanced into clinical testing, with similar to 60 more in pre-clinical development. Here, we discuss the emerging promise of nanotechnology in vaccine design and manufacturing to combat SARS-CoV-2, and highlight opportunities and challenges presented by these novel vaccine platforms. (C) 2021 The Authors. Published by Elsevier B.V.

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