Regulation of histone synthesis and nucleosome assembly

被引:95
作者
Gunjan, A
Paik, J
Verreault, A
机构
[1] Canc Res UK, London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England
[2] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
关键词
histone synthesis; nucleosome assembly; cell cycle; chromatin;
D O I
10.1016/j.biochi.2005.02.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Histone deposition onto nascent DNA is the first step in the process of chromatin assembly during DNA replication. The process of nucleosome assembly represents a daunting task for S-phase cells, partly because cells need to rapidly package nascent DNA into nucleosomes while avoiding the generation of excess histones. Consequently, cells have evolved a number of nucleosome assembly factors and regulatory mechanisms that collectively function to coordinate the rates of histone and DNA synthesis during both normal cell cycle progression and in response to conditions that interfere with DNA replication. (C) 2005 Elsevier SAS. All rights reserved.
引用
收藏
页码:625 / 635
页数:11
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