Impaired methionine and folate metabolism in colorectal carcinogenesis

被引：3
|
作者：
Moreiras, GV [1 ]
González, MP [1 ]
Alonso-Aperte, E [1 ]
机构：
[1] Univ San Pablo, CEU, Fac Farm, Dept Nutr Bromatol & Tecnol Alimentos, Madrid 28668, Spain
来源：
TRENDS IN FOOD SCIENCE & TECHNOLOGY | 2005年 / 16卷 / 6-7期
关键词：
D O I：
10.1016/j.tifs.2005.03.016
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Epidemiological and experimental studies suggest that folate may modulate colorectal carcinogenesis. Its role could be associated with the importance of tetrahydrofolate in DNA and RNA methylation, as well as in thymidylate and purine synthesis, essential for DNA synthesis and repair. In consequence, we analyzed the global DNA methylation and S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) colonic mucosa concentration in biopsies with polyps vs. control biopsies from the same patients (n=45). Significant colonic DNA global hypomethylation (p < 0.05) was found in injured tissue vs. control. Moreover, a lower 'methylation' ratio (SAM:SAH) was observed in pathological tissue (3.69 +/- 0.38) vs. control (5.00 +/- 0.63), due to a much higher SAH concentration (12.03 +/- 1.36 vs. 5.45 +/- 0.49 nmol/g).
引用
收藏
页码：282 / 288
页数：7
相关论文
共 50 条
  • [41] Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States
    Andrew Flood
    Laura Caprario
    Nilanjan Chaterjee
    James V. Lacey
    Catherine Schairer
    Arthur Schatzkin
    Cancer Causes & Control, 2002, 13 : 551 - 561
  • [42] Impaired DNA repair in the rat colon is a result of folate deficiency: Implications for colonic carcinogenesis
    Choi, SW
    Kim, YI
    Weitzel, JN
    Mason, JB
    GASTROENTEROLOGY, 1996, 110 (04) : A503 - A503
  • [43] The colorectal mucosa of old rats is more susceptible to folate depletion than young rats: Implications for folate-related colorectal carcinogenesis.
    Choi, SW
    Bagley, PJ
    Gee, A
    Tsui, K
    Mason, JB
    GASTROENTEROLOGY, 2000, 118 (04) : A70 - A70
  • [44] Dietary nickel and folic acid interact to affect folate and methionine metabolism in the rat
    Uthus, EO
    Poellot, RA
    BIOLOGICAL TRACE ELEMENT RESEARCH, 1997, 58 (1-2) : 25 - 33
  • [45] Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Kurzwelly, Delia
    Knop, Stefan
    Guenther, Markus
    Loeffler, Juergen
    Korfel, Agnieszka
    Thiel, Eckhard
    Hebart, Holger
    Simon, Matthias
    Weller, Michael
    Linnebank, Michael
    Herrlinger, Ulrich
    JOURNAL OF NEURO-ONCOLOGY, 2010, 100 (02) : 187 - 192
  • [46] EFFECTS OF DIETARY METHIONINE AND VITAMIN B12 DEFICIENCY ON FOLATE METABOLISM
    VITALE, JJ
    HEGSTED, DM
    BRITISH JOURNAL OF HAEMATOLOGY, 1969, 17 (05) : 467 - &
  • [47] Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Delia Kurzwelly
    Stefan Knop
    Markus Guenther
    Juergen Loeffler
    Agnieszka Korfel
    Eckhard Thiel
    Holger Hebart
    Matthias Simon
    Michael Weller
    Michael Linnebank
    Ulrich Herrlinger
    Journal of Neuro-Oncology, 2010, 100 : 187 - 192
  • [48] REGULATION OF COBALAMIN AND FOLATE METABOLISM BY METHIONINE IN HUMAN-BONE MARROW CULTURES
    SOURIAL, NA
    BROWN, L
    SCANDINAVIAN JOURNAL OF HAEMATOLOGY, 1983, 31 (05): : 413 - 423
  • [49] Dietary nickel and folic acid interact to affect folate and methionine metabolism in the rat
    Eric O. Uthus
    Rhonda A. Poellot
    Biological Trace Element Research, 1997, 58 : 25 - 33
  • [50] Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline
    Wilson, Fiona A.
    van den Borne, Joost J. G. C.
    Calder, A. Graham
    O'Kennedy, Niamh
    Holtrop, Grietje
    Rees, William D.
    Lobley, Gerald E.
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (04): : E702 - E713
12345