Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

被引：27

作者：

Adetifa, Ifedayo M. O. ^{[1
,2
]}

Uyoga, Sophie ^{[1
]}

Gitonga, John N. ^{[1
]}

Mugo, Daisy ^{[1
]}

Otiende, Mark ^{[1
]}

Nyagwange, James ^{[1
]}

Karanja, Henry K. ^{[1
]}

Tuju, James ^{[1
]}

Wanjiku, Perpetual ^{[1
]}

Aman, Rashid ^{[3
]}

Mwangangi, Mercy ^{[3
]}

Amoth, Patrick ^{[3
]}

Kasera, Kadondi ^{[3
]}

Ng'ang'a, Wangari ^{[4
]}

Rombo, Charles ^{[5
]}

Yegon, Christine ^{[5
]}

Kithi, Khamisi ^{[5
]}

Odhiambo, Elizabeth ^{[5
]}

Rotich, Thomas ^{[5
]}

Orgut, Irene ^{[5
]}

Kihara, Sammy ^{[5
]}

Bottomley, Christian ^{[2
]}

Kagucia, Eunice W. ^{[1
]}

Gallagher, Katherine E. ^{[1
,2
]}

Etyang, Anthony ^{[1
]}

Voller, Shirine ^{[1
,2
]}

Lambe, Teresa ^{[6
]}

Wright, Daniel ^{[6
]}

Barasa, Edwine ^{[1
]}

Tsofa, Benjamin ^{[1
]}

Bejon, Philip ^{[1
,6
]}

Ochola-Oyier, Lynette, I ^{[1
]}

Agweyu, Ambrose ^{[1
]}

Scott, J. Anthony G. ^{[1
,2
,6
]}

Warimwe, George M. ^{[1
,6
]}

机构：

[1] KEMRI Wellcome Trust Res Programme, Kilifi, Kenya

[2] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, Keppel St, London, England

[3] Govt Kenya, Minist Hlth, Nairobi, Kenya

[4] Govt Kenya, Presidential Policy & Strategy Unit, The Presidency, Nairobi, Kenya

[5] Minist Hlth, Kenya Natl Blood Transfus Serv, Nairobi, Kenya

[6] Univ Oxford, Nuffield Dept Med, Oxford, England

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

ANTI-SARS-COV-2 IGG ANTIBODIES;

D O I：

10.1038/s41467-021-24062-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The reported burden of SARS-CoV-2 has been relatively low in tropical Africa compared to Europe and the Americas, but estimating true infection rates is challenging. Here, the authors screen blood donors in Kenya for SARS-CoV-2 antibodies and describe spatiotemporal seroprevalence dynamics. Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

引用

页数：6

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