Bio-Fe3O4-MNPs catalyzed green synthesis of pyrrolo[2,1-a]isoquinoline derivatives using isoquinolium bromide salts: study of antioxidant activity

In this research, a novel, one-pot, efficient procedure with high yield for the synthesis of pyrrolo[2,1-a]isoquinoline derivatives using multi-component reaction of isoquinoline, alkyl bromides, and triphenylphosphine in the presence of Fe3O4-MNPs as catalyst under solvent-free conditions at room temperature is investigated. This study highlights an easy, simple, rapid, and clean method for the preparation of pyrrolo[2,1-a]isoquinoline derivatives. The Fe3O4-MNPs in these reactions were produced employing a green procedure by reduction of ferric chloride solution with pomegranate peel water extract. Additionally, antioxidant activity was studied for the some newly synthesized compounds such as 5a-5d using the DPPH radical trapping and reducing potential of ferric ion experiments and comparing the results with the results of synthetic antioxidants (2-tert-butylhydroquinone, TBHQ; butylated hydroxytoluene, BHT). As a result, compounds 5a-5d show trace DPPH radical trapping and excellent reducing power of ferric ion.