Is Diabetes Mellitus a Continuous Spectrum?

被引：34
作者：
Brooks-Worrell, Barbara [1 ,2 ]
Palmer, Jerry P. [1 ,2 ]
机构：
[1] DVA Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA
[2] Univ Washington, Dept Med, Seattle, WA USA
来源：
CLINICAL CHEMISTRY | 2011年 / 57卷 / 02期
关键词：
ISLET-CELL ANTIBODIES; BETA-CELL; INSULIN-RESISTANCE; ADULTS LADA; HUMORAL AUTOIMMUNITY; FAMILY-HISTORY; TYPE-1; RISK; PROGRESSION; ONSET;
D O I：
10.1373/clinchem.2010.148270
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
BACKGROUND: Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease. CONTENT: The current diabetes classification scheme needs to be reevaluated because of the accumulating evidence of immune system involvement in the pathophysiology of type 2 diabetes. SUMMARY: There are similarities and differences between type 1 and type 2 diabetes with regard to pathogenesis, pathophysiology, and genetics. We propose a resolution to the dilemma of the current classification scheme. (C) 2010 American Association for Clinical Chemistry
引用
收藏
页码：158 / 161
页数：4
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