Is Diabetes Mellitus a Continuous Spectrum?

被引：34

作者：

Brooks-Worrell, Barbara ^{[1
,2
]}

Palmer, Jerry P. ^{[1
,2
]}

机构：

[1] DVA Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA

[2] Univ Washington, Dept Med, Seattle, WA USA

来源：

CLINICAL CHEMISTRY | 2011年 / 57卷 / 02期

关键词：

ISLET-CELL ANTIBODIES; BETA-CELL; INSULIN-RESISTANCE; ADULTS LADA; HUMORAL AUTOIMMUNITY; FAMILY-HISTORY; TYPE-1; RISK; PROGRESSION; ONSET;

D O I：

10.1373/clinchem.2010.148270

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

BACKGROUND: Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease. CONTENT: The current diabetes classification scheme needs to be reevaluated because of the accumulating evidence of immune system involvement in the pathophysiology of type 2 diabetes. SUMMARY: There are similarities and differences between type 1 and type 2 diabetes with regard to pathogenesis, pathophysiology, and genetics. We propose a resolution to the dilemma of the current classification scheme. (C) 2010 American Association for Clinical Chemistry

引用

页码：158 / 161

页数：4

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