A Radical Bidirectional Fragment Coupling Route to Unsymmetrical Ketones

被引：29

作者：

Anthore-Dalion, Lucile ^{[1
]}

Liu, Qiang ^{[1
]}

Zard, Samir Z. ^{[1
]}

机构：

[1] Ecole Polytech, CNRS UMR 7652, Lab Synth Organ, F-91128 Palaiseau, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 27期

关键词：

ALPHA-ALKYLATION; ASYMMETRIC-SYNTHESIS; METHYL GROUP; ALCOHOLS; HYDROGEN; IRIDIUM; METHANOL; DERIVATIVES; XANTHATES; CATALYSIS;

D O I：

10.1021/jacs.6b05344

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A powerful strategy for the regioselective bidirectional synthesis of unsymmetrically substituted ketones is described, relying on the fact that the exchange of a xanthate is much faster than the radical addition to an unactivated alkene. The use of an alkene as the formal "alkylating" agent associated with the tolerance for numerous functional groups and the mildness of the experimental conditions removes many of the problems associated with the classical ionic and transition-metal-based approaches.

引用

页码：8404 / 8407

页数：4

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