AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

被引：307
作者：
Wunderlich, M. [1 ]
Chou, F-S [1 ]
Link, K. A. [1 ]
Mizukawa, B. [2 ]
Perry, R. L. [3 ]
Carroll, M. [4 ]
Mulloy, J. C. [1 ]
机构：
[1] Cincinnati Childrens Hosp, Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[2] Cincinnati Childrens Hosp, Med Ctr, Div Hematol & Oncol, Cincinnati, OH USA
[3] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
[4] Univ Penn, Div Hematol & Oncol, Philadelphia, PA 19104 USA
来源：
LEUKEMIA | 2010年 / 24卷 / 10期
关键词：
HEMATOPOIETIC STEM-CELLS; ACUTE MYELOID-LEUKEMIA; MODEL; ENGRAFTMENT;
D O I：
10.1038/leu.2010.158
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1785 / 1788
页数：4
相关论文
共 10 条
  • [1] Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors
    Feuring-Buske, M
    Gerhard, B
    Cashman, J
    Humphries, RK
    Eaves, CJ
    Hogge, DE
    [J]. LEUKEMIA, 2003, 17 (04) : 760 - 763
  • [2] NOD/SCID/γcnull mouse:: an excellent recipient mouse model for engraftment of human cells
    Ito, M
    Hiramatsu, H
    Kobayashi, K
    Suzue, K
    Kawahata, M
    Hioki, K
    Ueyama, Y
    Koyanagi, Y
    Sugamura, K
    Tsuji, K
    Heike, T
    Nakahata, T
    [J]. BLOOD, 2002, 100 (09) : 3175 - 3182
  • [3] Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    Mulloy, JC
    Cammenga, J
    Berguido, FJ
    Wu, KD
    Zhou, P
    Comenzo, RL
    Jhanwar, S
    Moore, MAS
    Nimer, SD
    [J]. BLOOD, 2003, 102 (13) : 4369 - 4376
  • [4] The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
    Mulloy, JC
    Cammenga, J
    MacKenzie, KL
    Berguido, FJ
    Moore, MAS
    Nimer, SD
    [J]. BLOOD, 2002, 99 (01) : 15 - 23
  • [5] NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration
    Nicolini, FE
    Cashman, JD
    Hogge, DE
    Humphries, RK
    Eaves, CJ
    [J]. LEUKEMIA, 2004, 18 (02) : 341 - 347
  • [6] A robust xenotransplantation model for acute myeloid leukemia
    Sanchez, P. V.
    Perry, R. L.
    Sarry, J. E.
    Perl, A. E.
    Murphy, K.
    Swider, C. R.
    Bagg, A.
    Choi, J. K.
    Biegel, J. A.
    Danet-Desnoyers, G.
    Carroll, M.
    [J]. LEUKEMIA, 2009, 23 (11) : 2109 - 2117
  • [7] Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2Rγnull mice engrafted with mobilized human hemopoietic stem cells
    Shultz, LD
    Lyons, BL
    Burzenski, LM
    Gott, B
    Chen, XH
    Chaleff, S
    Kotb, M
    Gillies, SD
    King, M
    Mangada, J
    Greiner, DL
    Handgretinger, R
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (10) : 6477 - 6489
  • [8] Humanized mice in translational biomedical research
    Shultz, Leonard D.
    Ishikawa, Fumihiko
    Greiner, Dale L.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2007, 7 (02) : 118 - 130
  • [9] Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
    Wei, Junping
    Wunderlich, Mark
    Fox, Catherine
    Alvarez, Sara
    Cigudosa, Juan C.
    Wilhelm, Jamie S.
    Zheng, Yi
    Cancelas, Jose A.
    Gu, Yi
    Jansen, Michael
    DiMartino, Jorge F.
    Mulloy, James C.
    [J]. CANCER CELL, 2008, 13 (06) : 483 - 495
  • [10] Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
    Wunderlich, Mark
    Krejci, Ondrej
    Wei, Junping
    Mulloy, James C.
    [J]. BLOOD, 2006, 108 (05) : 1690 - 1697
1